Allergy / Immunology
7 EDS specialists in this category
Allergists and immunologists who understand EDS evaluate and treat the mast cell activation syndrome (MCAS) and allergic-type reactions that commonly overlap with Ehlers-Danlos Syndrome. MCAS in EDS patients can cause flushing, hives, GI distress, anaphylaxis-like episodes, and brain fog — ask whether the provider tests for both tryptase and prostaglandin D2 levels. Treatment typically involves a combination of H1 and H2 antihistamines, mast cell stabilizers like cromolyn sodium, and trigger avoidance strategies. An experienced allergist will also evaluate for common EDS-related immune issues including recurrent infections and medication sensitivities.
Allergy / Immunology specialists are most concentrated in Arizona (1), California (1), North Carolina (1).
Last updated 2026-04-18
About Allergy / Immunology for EDS Patients
Many EDS patients experience allergic-type reactions that seem to come out of nowhere — hives, flushing, stomach problems, or feeling like you're having an allergic reaction without a clear trigger. An allergist who understands EDS can evaluate whether mast cell activation syndrome (MCAS) is involved, which is common in connective tissue disorders.
What to Expect
Your first appointment will likely include a detailed history of your reactions, triggers, and medications. The doctor may order blood and urine tests to check mast cell markers like tryptase and prostaglandin levels. Bring a list of all your symptoms and any patterns you've noticed — even ones that seem unrelated, like brain fog or GI issues, since MCAS can affect many body systems.